Данилов Лаврентий Глебович

Основные компетенции:

Проведение биоинформатического анализа метагеномных данных — анализ полногеномных данных и данных ампликонного секвенирования с дополнительной статистичекой обработкой и анализом метаболических путей.

Проведение биоинформатического анализа транскриптомных данных — сборка транскриптомов и анализ дифференциальной экспресии

Проведение биоинформатического анализа геномных данных — сборка и аннотация геномов, GWAS анализ

Планирование и дизайн эксперимента для медицинских исследований.

Сопровождение медико-генетических проектов коммерческой, образовательной, научной направленности.

Научные интересы:

• Биоинформатический анализ метагеномных данных, дизайн метагеномных экспериментов
• Анализ транскриптомных данных (включая сборку транскриптомов)
• Анализ протеомных данных
• Статистический анализ медицинских данных
• Функцинальные амилоиды

Публикации:

• Conservation of an Agrobacterium cT-DNA insert in Camellia section Thea reveals the ancient origin of tea plants from a genetically modified ancestor. Ke Chen, Peter Zhurbenko, Lavrentii Danilov, Tatiana Matveeva and Léon Otten, 2022, Frontiers in Plant Science, P. 4962
• Phylogeography of the closely related Littorina (Neritrema) species in the North-East Atlantic. A.L. Maltseva, A.Z. Panova, M.A. Varfolomeeva, D.V. Vikhreva, D.V. Smutin, P.A. Pavlova, G.P. Maslakov, L.G. Danilov, N.A. Mikhailova, A.I. Granovitch, 2022, Invertebrate Zoology, Vol. 19. – No 4. – P. 404–424
• Clinical and Genetic Characteristics of Pediatric Patients with Hypophosphatasia in the Russian Population Oleg S. Glotov, Kirill V. Savostyanov, Tatyana S. Nagornova, Alexandr N. Chernov, Mikhail A. Fedyakov, Aleksandra N. Raspopova, Konstantin N. Krasnoukhov, Lavrentii G. Danilov, Nadegda V. Moiseeva, Roman S. Kalinin, Victoria V. Tsai, Yuri A. Eismont, Victoria Y. Voinova, Alisa V. Vitebskaya, Elena Y. Gurkina, Ludmila M. Kuzenkova, Irina B. Sosnina, Alexander A. Pushkov, Ilya S. Zhanin and Ekaterina Y. Zakharova, 2022, International Journal of Molecular Sciences, Vol. 23. – No. 21. – P. 12976.
• Data on RNA-seq analysis of the oviducts of five closely related species genus Littorina (Mollusca, Caenogastropoda): L. saxatilis, L. arcana, L. compressa, L. Obtusata, L. fabalis; Arseniy A.Lobov, Lavrentii G.Danilov, Alexey E.Masharskiy, Alexander V.Predeus, Natalia A.Mikhailova, Andrei I.Granovitch, Arina L.Maltseva, 2022, Data in brief,42,108122;
• Orphan gene in Littorina: An unexpected role of symbionts in the host evolution; A.L.Maltseva, A.A.Lobov, P.A.Pavlovа, M.Panova, E.R.Gafarova, J.P.Marques, L.G.Danilov, A.I.Granovitch, 2022, Gene,3263:49:00;
• “Chapter 3. The Current State of Molecular Genetic Diagnostics in Various Forms of Osteogenesis Imperfecta”; Sergey Khalchitsky, Marina Sogoyan, Alina Li-Zablockaya, Lavrentii Danilov, Vladislav Muldiyarov, Dmitry Buklaev, and Sergey Vissarionov, 2022, Nova Science Publishers, Inc., Osteogenesis Imperfecta: From Diagnosis to Treatment.
• Transcriptome analysis of crown gall in radish (Raphanus sativus L.) inbred lines; Alexander A.Tkachenko, Maria S.Gancheva, Varvara E.Tvorogova, Lavrenty G.Danilov, Alexander V.Predeus, Irina E.Dodueva, Ludmila L.Lutova, 2021, Annals of Applied Biology,178:3:527-548;
• The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo; Lavrentii G.Danilov, Svetlana E.Moskalenko, Andrew G.Matveenko, Xenia V.Sukhanova, Mikhail V.Belousov, Galina A.Zhouravleva, Stanislav A.Bondarev, 2021, Biomedicines, 9:10:1451;
• Chromosome-level genome assembly and structural variant analysis of two laboratory yeast strains from the Peterhof Genetic Collection lineage; Yury A.Barbitoff, Andrew G.Matveenko, Anton B.Matiiv, Evgeniia M.Maksiutenko, Svetlana E.Moskalenko, Polina B.Drozdova, Dmitrii E.Polev, Alexandra Y.Beliavskaia, Lavrentii G.Danilov, Alexander V.Predeus, Galina A.Zhouravleva, 2021, G3: Genes, Genomes, Genetics,11:4:jkab029;
• Species-Specific Proteins in the Oviducts of Snail Sibling Species: Proteotranscriptomic Study of Littorina fabalis and L. obtusata; Arseniy A.Lobov, Irina Y.Babkina, Lavrentii G.Danilov, Alexey E.Masharskiy, Alexander V.Predeus, Natalia A.Mikhailova, Andrei I.Granovitch, Arina L.Maltseva, 2021, Biology, 10:29:07;
• Pattern of Repetitive Element Transcription Segregate Cell Lineages during the Embryogenesis of Sea Urchin Strongylocentrotus purpuratus; Nick Panyushev, Larisa Okorokova, Lavrentii Danilov, Leonid Adonin,2021, Biomedicines,9(11), 1736;
• De novo transcriptome assembly and annotation of parthenogenetic lizard Darevskia unisexualis and its parental ancestors Darevskia valentini and Darevskia raddei nairensis, Sergei S.Ryakhovsky, Victoria A.Dikaya, Vitaly I.Korchagin, Andrey A.Vergun, Lavrentii G.Danilov, Sofia D.Ochkalova, Anastasiya E.Girnyk, Daria V.Zhernakova, Marine S.Arakelyan, Vladimir B.Brukhin, Aleksey S.Komissarov, Alexey P.Ryskov, 2021; Data in brief, 39, 107685;

Design of a New [PSI+]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI+] Prion Propagation, Lavrentii G.Danilov, Andrew G.Matveenko, Varvara E.Ryzhkova, Mikhail V.Belousov, Olga I.Poleshchuk, Daria V.Likholetova, Petr A.Sokolov, Nina A.Kasyanenko, Andrey V.Kajava, Galina A.Zhouravleva, Stanislav A.Bondarev, 2019; Frontiers in Molecular Neuroscience, 12:274;